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Clofarabine.
[No authors listed] [No authors listed] 2017 Oct 17. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2017 Oct 17. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31643513 Free Books & Documents. Review.
Clofarabine is a purine analogue and antineoplastic agent used in the therapy of acute lymphoblastic leukemia (ALL) in children. Clofarabine is associated with frequent transient serum enzyme elevations during therapy, but they are usually asymptomatic and transient …
Clofarabine is a purine analogue and antineoplastic agent used in the therapy of acute lymphoblastic leukemia (ALL) in children. C …
Clofarabine.
Pui CH, Jeha S. Pui CH, et al. Nat Rev Drug Discov. 2005 May;Suppl:S12-3. doi: 10.1038/nrd1724. Nat Rev Drug Discov. 2005. PMID: 15962525 Review.
Clofarabine (Clolar; Genzyme), a purine nucleoside antimetabolite, was granted accelerated approval by the US FDA for the treatment of paediatric patients with relapsed or refractory acute lymphoblastic leukaemia in December 2004. ...
Clofarabine (Clolar; Genzyme), a purine nucleoside antimetabolite, was granted accelerated approval by the US FDA for the treatment o …
Clofarabine in leukemia.
Ghanem H, Jabbour E, Faderl S, Ghandhi V, Plunkett W, Kantarjian H. Ghanem H, et al. Expert Rev Hematol. 2010 Feb;3(1):15-22. doi: 10.1586/ehm.09.70. Expert Rev Hematol. 2010. PMID: 21082931 Review.
Clofarabine is a second-generation purine nucleoside analogue that has been synthesized to overcome the limitations and incorporate the best qualities of fludarabine and cladribine. Clofarabine acts by inhibiting ribonucleotide reductase and DNA polymerase, thereby …
Clofarabine is a second-generation purine nucleoside analogue that has been synthesized to overcome the limitations and incorporate t …
Clofarabine.
[No authors listed] [No authors listed] Drugs R D. 2004;5(4):213-7. doi: 10.2165/00126839-200405040-00005. Drugs R D. 2004. PMID: 15230627 Review.
The companies are planning to investigate the potential use of clofarabine in combination with DNA-damaging agents, because clofarabine has been shown to inhibit DNA repair and may, therefore, potentiate the effects of DNA damaging drugs. ...In addition, ILEX said i …
The companies are planning to investigate the potential use of clofarabine in combination with DNA-damaging agents, because clofar …
Clofarabine.
Pui CH, Jeha S, Kirkpatrick P. Pui CH, et al. Nat Rev Drug Discov. 2005 May;4(5):369-70. doi: 10.1038/nrd1724. Nat Rev Drug Discov. 2005. PMID: 15902772 No abstract available.
Clofarabine (2-chloro-2'-fluoro-2'-deoxyarabinosyladenine)--biochemical aspects of anticancer activity.
Majda K, Lubecka K, Kaufman-Szymczyk A, Fabianowska-Majewska K. Majda K, et al. Acta Pol Pharm. 2011 Jul-Aug;68(4):459-66. Acta Pol Pharm. 2011. PMID: 21796927 Free article. Review.
Clofarabine (2-chloro-2'-fluoro-2'-deoxyarabinosyladenine) is a second generation analogue of 2'-deoxyadenosine connecting biochemical activities of its prototypes: cladribine (2-chloro-2'-deoxyadenosine) and fludarabine (2-fluoro-arabinosyladenine). ...Encouraging results …
Clofarabine (2-chloro-2'-fluoro-2'-deoxyarabinosyladenine) is a second generation analogue of 2'-deoxyadenosine connecting biochemica …
Clofarabine: past, present, and future.
Kantarjian HM, Jeha S, Gandhi V, Wess M, Faderl S. Kantarjian HM, et al. Leuk Lymphoma. 2007 Oct;48(10):1922-30. doi: 10.1080/10428190701545644. Leuk Lymphoma. 2007. PMID: 17852710 Review.
Clofarabine is a good generation purine nucleoside analogue designed to overcome the limitations and to incorporate the best qualities of both cladribine and fludarabine. Clofarabine is thought to work via three mechanisms: inhibition of ribonucleotide reductase; in …
Clofarabine is a good generation purine nucleoside analogue designed to overcome the limitations and to incorporate the best qualitie …
Clofarabine for myelodysplastic syndromes.
Tiu RV, Traina F, Sekeres MA. Tiu RV, et al. Expert Opin Investig Drugs. 2011 Jul;20(7):1005-14. doi: 10.1517/13543784.2011.585967. Epub 2011 May 19. Expert Opin Investig Drugs. 2011. PMID: 21591997 Review.
Although myelosuppression is an important side effect, clofarabine is generally well tolerated in MDS. Clofarabine is currently available in an intravenous form with an oral formulation presently under investigation, either as a single agent or in combination therap …
Although myelosuppression is an important side effect, clofarabine is generally well tolerated in MDS. Clofarabine is currentl …
Patient-Level Meta-analysis of Clofarabine in Acute Lymphoblastic Leukemia.
Jeha S, Goto H, Baruchel A, Boëlle-Le Corfec E, Geffriaud-Ricouard C, Pieters R, Shin HY. Jeha S, et al. Adv Ther. 2023 Dec;40(12):5447-5463. doi: 10.1007/s12325-023-02696-7. Epub 2023 Oct 11. Adv Ther. 2023. PMID: 37819554 Free PMC article.
To address a post-marketing requirement for additional evidence of the clinical benefit of clofarabine in its approved indication, a meta-analysis of patient-level data was conducted. ...No new safety signals were identified. Results support the use of clofarabine m …
To address a post-marketing requirement for additional evidence of the clinical benefit of clofarabine in its approved indication, a …
Clofarabine in the treatment of newly diagnosed acute myeloid leukemia in older adults.
Tran H, Yang D. Tran H, et al. Ann Pharmacother. 2012 Jan;46(1):89-96. doi: 10.1345/aph.1Q295. Epub 2011 Dec 13. Ann Pharmacother. 2012. PMID: 22170975 Review.
DATA SYNTHESIS: Two studies evaluating clofarabine as monotherapy and 2 studies evaluating clofarabine in combination with cytarabine were reviewed. ...Compared to single-agent clofarabine, response rates and median OS were higher for clofarabine combi …
DATA SYNTHESIS: Two studies evaluating clofarabine as monotherapy and 2 studies evaluating clofarabine in combination with cyt …
631 results

Searches related to "clofarabine"