Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2005 2
2006 1
2007 3
2008 6
2009 3
2010 6
2011 11
2012 6
2013 7
2014 15
2015 10
2016 12
2017 11
2018 7
2019 8
2020 11
2021 17
2022 17
2023 12
2024 5

Text availability

Article attribute

Article type

Publication date

Search Results

147 results

Results by year

Filters applied: . Clear all
Page 1
Givinostat: an emerging treatment for polycythemia vera.
Chifotides HT, Bose P, Verstovsek S. Chifotides HT, et al. Expert Opin Investig Drugs. 2020 Jun;29(6):525-536. doi: 10.1080/13543784.2020.1761323. Epub 2020 Jul 21. Expert Opin Investig Drugs. 2020. PMID: 32693648 Free PMC article. Review.
Givinostat was well tolerated and yielded promising clinico-hematological responses. A phase III study of givinostat versus hydroxyurea in high-risk PV patients is planned. AREAS COVERED: We present an overview of PV, current treatment guidelines, and the putative m
Givinostat was well tolerated and yielded promising clinico-hematological responses. A phase III study of givinostat versus hy
Population pharmacokinetic-pharmacodynamic analysis of givinostat.
Fiorentini F, Germani M, Del Bene F, Pellizzoni C, Cazzaniga S, Rocchetti M, Bettica P. Fiorentini F, et al. Expert Opin Drug Metab Toxicol. 2023 Apr;19(4):229-238. doi: 10.1080/17425255.2023.2219839. Epub 2023 Jun 12. Expert Opin Drug Metab Toxicol. 2023. PMID: 37306105 Clinical Trial.
BACKGROUND: Givinostat (ITF2357), an oral, synthetic histone deacetylase inhibitor, significantly improved all histological muscle biopsy parameters in a Phase II study in boys with Duchenne muscular dystrophy (DMD). ...A PK/pharmacodynamic (PD) model was developed to simu …
BACKGROUND: Givinostat (ITF2357), an oral, synthetic histone deacetylase inhibitor, significantly improved all histological muscle bi …
Givinostat for Becker muscular dystrophy: A randomized, placebo-controlled, double-blind study.
Comi GP, Niks EH, Vandenborne K, Cinnante CM, Kan HE, Willcocks RJ, Velardo D, Magri F, Ripolone M, van Benthem JJ, van de Velde NM, Nava S, Ambrosoli L, Cazzaniga S, Bettica PU. Comi GP, et al. Front Neurol. 2023 Jan 30;14:1095121. doi: 10.3389/fneur.2023.1095121. eCollection 2023. Front Neurol. 2023. PMID: 36793492 Free PMC article.
METHODS: Males aged 18-65 years with a diagnosis of BMD confirmed by genetic testing were randomized 2:1 to 12 months treatment with givinostat or placebo. The primary objective was to demonstrate statistical superiority of givinostat over placebo for mean change fr …
METHODS: Males aged 18-65 years with a diagnosis of BMD confirmed by genetic testing were randomized 2:1 to 12 months treatment with givi
Givinostat Inhibition of Sp1-dependent MGMT Expression Sensitizes Glioma Stem Cells to Temozolomide.
Nakagawa-Saito Y, Mitobe Y, Togashi K, Suzuki S, Sugai A, Kitanaka C, Okada M. Nakagawa-Saito Y, et al. Anticancer Res. 2023 Mar;43(3):1131-1138. doi: 10.21873/anticanres.16258. Anticancer Res. 2023. PMID: 36854532
BACKGROUND/AIM: Givinostat is a pan-histone deacetylase (HDAC) inhibitor that has demonstrated excellent tolerability as well as efficacy in patients with polycythemia vera. ...Givinostat inhibited MGMT expression in GSCs and, in parallel, the expression of Sp1, a t …
BACKGROUND/AIM: Givinostat is a pan-histone deacetylase (HDAC) inhibitor that has demonstrated excellent tolerability as well as effi …
Histone deacetylase inhibitor givinostat attenuates nonalcoholic steatohepatitis and liver fibrosis.
Huang HM, Fan SJ, Zhou XR, Liu YJ, Li X, Liao LP, Huang J, Shi CC, Yu L, Fu R, Fan JG, Zhang YY, Luo C, Li GM. Huang HM, et al. Acta Pharmacol Sin. 2022 Apr;43(4):941-953. doi: 10.1038/s41401-021-00725-1. Epub 2021 Aug 2. Acta Pharmacol Sin. 2022. PMID: 34341511 Free PMC article.
The benefit of givinostat was further confirmed in FPC-induced NASH mice. Givinostat administration significantly attenuated hepatic steatosis, inflammation as well as liver injury in this mouse model. In conclusion, givinostat is efficacious in reversing die …
The benefit of givinostat was further confirmed in FPC-induced NASH mice. Givinostat administration significantly attenuated h …
Analysis of Givinostat/ITF2357 Treatment in a Rat Model of Neonatal Hypoxic-Ischemic Brain Damage.
Pawelec P, Sypecka J, Zalewska T, Ziemka-Nalecz M. Pawelec P, et al. Int J Mol Sci. 2022 Jul 27;23(15):8287. doi: 10.3390/ijms23158287. Int J Mol Sci. 2022. PMID: 35955430 Free PMC article.
Givinostat treatment did not modulate the microglial response specific for HI injury. ...Givinostat/ITF2357 did not prevent an inflammatory reaction after HI....
Givinostat treatment did not modulate the microglial response specific for HI injury. ...Givinostat/ITF2357 did not prevent an
Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation.
Wang YG, Xu L, Wang T, Wei J, Meng WY, Wang N, Shi M. Wang YG, et al. World J Gastroenterol. 2015 Jul 21;21(27):8326-39. doi: 10.3748/wjg.v21.i27.8326. World J Gastroenterol. 2015. PMID: 26217084 Free PMC article.
AIM: To explore the effect of the histone deacetylase inhibitor givinostat on proteins related to regulation of hepatic stellate cell proliferation. ...The scratch assay was used to analyze the effect of givinostat on cell migration. Effects of givinostat on …
AIM: To explore the effect of the histone deacetylase inhibitor givinostat on proteins related to regulation of hepatic stellate cell …
Histone deacetylase inhibitor givinostat has ameliorative effect in the colitis model.
Dibekoğlu C, Erbaş O. Dibekoğlu C, et al. Acta Cir Bras. 2022 Jul 22;37(5):e370503. doi: 10.1590/acb370503. eCollection 2022. Acta Cir Bras. 2022. PMID: 35894303 Free PMC article.
PURPOSE: To investigate the effect of givinostat treatment in acetic acid-induced ulcerative colitis model in rats. ...Twenty rats with colitis were randomly divided into two groups. %0.9 NaCl (saline) solution was administered intraperitoneally to the first group of rats …
PURPOSE: To investigate the effect of givinostat treatment in acetic acid-induced ulcerative colitis model in rats. ...Twenty rats wi …
Givinostat as metabolic enhancer reverting mitochondrial biogenesis deficit in Duchenne Muscular Dystrophy.
Giovarelli M, Zecchini S, Catarinella G, Moscheni C, Sartori P, Barbieri C, Roux-Biejat P, Napoli A, Vantaggiato C, Cervia D, Perrotta C, Clementi E, Latella L, De Palma C. Giovarelli M, et al. Pharmacol Res. 2021 Aug;170:105751. doi: 10.1016/j.phrs.2021.105751. Epub 2021 Jun 29. Pharmacol Res. 2021. PMID: 34197911
We also observe a progressive mitochondrial biogenesis impairment associated with increased deacetylation of peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1alpha) promoter. Such histone deacetylation is inhibited by givinostat that positively mo …
We also observe a progressive mitochondrial biogenesis impairment associated with increased deacetylation of peroxisome proliferator-activat …
Givinostat exhibits in vitro synergy with posaconazole against Aspergillus spp.
Sun Y, Gao L, He C, Wu Q, Li M, Zeng T. Sun Y, et al. Med Mycol. 2017 Oct 1;55(7):798-802. doi: 10.1093/mmy/myw131. Med Mycol. 2017. PMID: 27915302
The results revealed favorable synergistic effects between givinostat and posaconazole (83.3%) against Aspergillus isolates. Limited synergism was observed when givinostat was combined with itraconazole or voriconazole. No interaction was observed between givinos
The results revealed favorable synergistic effects between givinostat and posaconazole (83.3%) against Aspergillus isolates. Limited …
147 results