Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2011 5
2012 3
2013 2
2014 2
2015 3
2016 3
2017 6
2018 1
2019 9
2020 7
2021 5
2022 6
2023 3
2024 3

Text availability

Article attribute

Article type

Publication date

Search Results

53 results

Results by year

Filters applied: . Clear all
Page 1
Histone deacetylase inhibitor pracinostat suppresses colorectal cancer by inducing CDK5-Drp1 signaling-mediated peripheral mitofission.
Liang XL, Ouyang L, Yu NN, Sun ZH, Gui ZK, Niu YL, He QY, Zhang J, Wang Y. Liang XL, et al. J Pharm Anal. 2023 Oct;13(10):1168-1182. doi: 10.1016/j.jpha.2023.06.005. Epub 2023 Jun 10. J Pharm Anal. 2023. PMID: 38024857 Free PMC article.
CRC cells with high level of CDK5 (CDK5-high) displayed midzone mitochondrial division that was associated with oncogenic phenotype, but treatment with pracinostat led to a lethal increase in the already-elevated level of CDK5 in the CRC cells. Mechanistically, pracinos …
CRC cells with high level of CDK5 (CDK5-high) displayed midzone mitochondrial division that was associated with oncogenic phenotype, but tre …
Histone deacetylase inhibitor pracinostat in doublet therapy: a unique strategy to improve therapeutic efficacy and to tackle herculean cancer chemoresistance.
Ganai SA. Ganai SA. Pharm Biol. 2016 Sep;54(9):1926-35. doi: 10.3109/13880209.2015.1135966. Epub 2016 Feb 5. Pharm Biol. 2016. PMID: 26853619 Review.
Methods Both old and the latest literature on pracinostat was retrieved from diverse sources, such as PubMed, Science Direct, Springer Link, general Google search using both pracinostat and SB939 keywords in various ways: after thorough evaluation the topic which ca …
Methods Both old and the latest literature on pracinostat was retrieved from diverse sources, such as PubMed, Science Direct, Springe …
The novel histone deacetylase inhibitor pracinostat suppresses the malignant phenotype in human glioma.
Chen M, Zhang L, Zhan R, Zheng X. Chen M, et al. Mol Biol Rep. 2022 Aug;49(8):7507-7519. doi: 10.1007/s11033-022-07559-y. Epub 2022 May 27. Mol Biol Rep. 2022. PMID: 35622308
In addition, pracinostat inhibited both the PI3K/Akt signaling pathway and the STAT3 pathway. CONCLUSIONS: Our results strongly support the potential clinical use of pracinostat as a novel therapy for human glioma in the near future....
In addition, pracinostat inhibited both the PI3K/Akt signaling pathway and the STAT3 pathway. CONCLUSIONS: Our results strongly suppo …
Pracinostat plus azacitidine in older patients with newly diagnosed acute myeloid leukemia: results of a phase 2 study.
Garcia-Manero G, Abaza Y, Takahashi K, Medeiros BC, Arellano M, Khaled SK, Patnaik M, Odenike O, Sayar H, Tummala M, Patel P, Maness-Harris L, Stuart R, Traer E, Karamlou K, Yacoub A, Ghalie R, Giorgino R, Atallah E. Garcia-Manero G, et al. Blood Adv. 2019 Feb 26;3(4):508-518. doi: 10.1182/bloodadvances.2018027409. Blood Adv. 2019. PMID: 30760466 Free PMC article. Clinical Trial.
Pracinostat, a potent oral pan-histone deacetylase inhibitor with modest single-agent activity in acute myeloid leukemia (AML), has shown synergistic antitumor activity when combined with azacitidine. ...Patients received pracinostat 60 mg/d, 3 d/wk, for 3 consecuti …
Pracinostat, a potent oral pan-histone deacetylase inhibitor with modest single-agent activity in acute myeloid leukemia (AML), has s …
A phase 2 study of pracinostat combined with ruxolitinib in patients with myelofibrosis.
Bose P, Swaminathan M, Pemmaraju N, Ferrajoli A, Jabbour EJ, Daver NG, DiNardo CD, Alvarado Y, Yilmaz M, Huynh-Lu J, Qiao W, Wang X, Matamoros A, Zhou L, Pierce S, Schroeder KD, Kantarjian HM, Verstovsek S. Bose P, et al. Leuk Lymphoma. 2019 Jul;60(7):1767-1774. doi: 10.1080/10428194.2018.1543876. Epub 2019 Jan 11. Leuk Lymphoma. 2019. PMID: 30632841 Free PMC article. Clinical Trial.
All patients discontinued pracinostat and are currently off-study. Pracinostat interruptions and dose reductions were frequent, often due to worsening anemia. These findings do not support continued development of pracinostat in myelofibrosis....
All patients discontinued pracinostat and are currently off-study. Pracinostat interruptions and dose reductions were frequent …
Minor structural modifications to Pracinostat produce big changes in its biological responses.
Jia R, Sun P, Zhang Y, Ge Y, Yu N. Jia R, et al. Chem Biol Drug Des. 2019 Aug;94(2):1488-1493. doi: 10.1111/cbdd.13527. Epub 2019 Apr 29. Chem Biol Drug Des. 2019. PMID: 30932330
A series of compounds similar to Pracinostat that contained benzimidazole ring and N-hydroxyacrylamide attached at 5- or 6-position were designed, synthesized, and evaluated as HDAC inhibitors. ...
A series of compounds similar to Pracinostat that contained benzimidazole ring and N-hydroxyacrylamide attached at 5- or 6-position w …
Study of the antilymphoma activity of pracinostat reveals different sensitivities of DLBCL cells to HDAC inhibitors.
Mensah AA, Spriano F, Sartori G, Priebe V, Cascione L, Gaudio E, Tarantelli C, Civanelli E, Aresu L, Rinaldi A, Damia G, Lovati E, Zucca E, Stathis A, Pietra C, Bertoni F. Mensah AA, et al. Blood Adv. 2021 May 25;5(10):2467-2480. doi: 10.1182/bloodadvances.2020003566. Blood Adv. 2021. PMID: 33999145 Free PMC article.
DLBCL xenograft models enabled assessment of the in vivo antilymphoma activity of pracinostat. Combination treatments with pracinostat plus 10 other antilymphoma agents were performed. ...Pharmacologic inhibition of antioxidant production rescued sensitivity of OxPh …
DLBCL xenograft models enabled assessment of the in vivo antilymphoma activity of pracinostat. Combination treatments with pracino …
53 results

Searches related to "pracinostat"